Factor Xa

Fxa

Factor Xa

Related Products

Factor Xa, a trypsin-like serine protease, is situated at the critical juncture between the intrinsic and extrinsic pathways, catalyzing the conversion of prothrombin to thrombin, and hence plays a pivotal role in the final common pathway of the cascade and has become an important target in the discovery and development of new anticoagulants. Factor Xa is a key protease of the coagulation pathway whose activity is known to be in part modulated by binding to factor Va and sodium ions.

Blood coagulation involves a complex cascade of enzymatic reactions, ultimately generating fibrin, the basis of all blood clots. This cascade is comprised of two arms, the intrinsic and extrinsic pathways which converge at factor Xa to form the common pathway. Factor Xa activates prothrombin to thrombin, which in turn catalyzes the conversion of fibrinogen to fibrin.

Factor Xa Related Products (82)
Antibodies (1)

By Effects:	Inhibitors (72) Modulator (1) Chemicals (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-153829

CH3OCO-D-CHA-Gly-Arg-pNA acetate		98.88%
CH3OCO-D-CHA-Gly-Arg-pNA acetate is a chromogenic substrate for factor Xa.

HY-P6023B

D-Leu-Pro-Arg-Rh110-D-Pro acetate	Modulator
D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity.

HY-P990060

Denecimig	Inhibitor
Denecimig (Mim8) is a novel activated coagulation factor VIII-mimetic human bispecific antibody with anti-FIXa and anti-FX arms that potently stimulates FX activation resulting in efficacious haemostasis in vitro and in vivo.

HY-10268B

Betrixaban hydrochloride	Inhibitor
Betrixaban (PRT054021) hydrochloride is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban hydrochloride shows antithrombotic effect.

HY-128889

FXIa-IN-1	Inhibitor
FXIa-IN-1 (compound EP-7041) is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.

HY-10264C

Edoxaban hydrochloride	Inhibitor
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with K_i values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research.

HY-10268A

Betrixaban maleate	Inhibitor
Betrixaban (PRT054021) maleate is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban maleate shows antithrombotic effect.

HY-11091

Razaxaban hydrochloride	Inhibitor
Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active factor Xa inhibitor with a K_i of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a K_i of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity.

HY-50903R

Rivaroxaban (Standard)	Inhibitor
Rivaroxaban (Standard) is the analytical standard of Rivaroxaban. This product is intended for research and analytical applications. Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC₅₀ 0.7 nM; K_i 0.4 nM).

HY-10724

Fidexaban	Inhibitor
Fidexaban is a Factor Xa inhibitor and can be used in research of cardiovascular disease.

HY-10594

Letaxaban	Inhibitor
Letaxaban (TAK-442) is an orally active and selective direct FXa inhibitor. Letaxaban is a drug with dual anticoagulant and anti-inflammatory activity that works by directly inhibiting FXa and by intervening in the PAR1 signaling pathway. Letaxaban can be used in the study of thrombotic diseases, cardiovascular diseases and inflammation-related diseases.

HY-10777

EMD 495235	Inhibitor
EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC₅₀ of 5.5 nM and a K_i of 6.8 nM. EMD 495235 shows anticoagulant activities.

HY-105919

Naroparcil	Inhibitor
Naroparcil is an orally active antithrombotic agent. Naroparcil exhibits antithrombotic effects in rabbit Wessler stasis model with EC₅₀s of 21.9 mg/kg and 36.0 mg/kg after respectively intravenous injection and oral administration.

HY-10278

Razaxaban	Inhibitor
F5&" is a bioavtive small molecular compound."

HY-145349

FXIa-IN-6	Inhibitor
FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (K_i = 0.3 nM).

HY-P4576

Methoxycarbonyl-D-Nle-Gly-Arg-pNA
Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin that can serve as a substrate for coagulation factors IXa (FIXa) and Xa (FXa).

HY-10722

DX-9065a	Inhibitor
DX-9065a is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a K_i of 41 nM for human FXa. DX-9065a has low activity against other serine proteases. DX-9065a has strong anticoagulant actions.

HY-11090A

DPC423	Inhibitor
DPC423 is a highly potent, selective, and orally active factor Xa inhibitor with a K_i of 0.15 nM.

HY-P6023

D-Leu-Pro-Arg-Rh110-D-Pro	Chemical
D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity.

HY-145354

FXIa-IN-7	Inhibitor
FXIa-IN-7 is a selective and orally bioavailable factor XIa inhibitor with an IC₅₀ value of 0.4 nM.

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Factor Xa

Factor Xa

Factor Xa Related Products (82)

Antibodies (1)

Factor Xa Related Products (82):